| Player | Beat Defending Champ |
|---|---|
| Andre Agassi | 6 --- AO 2, RG 2, US 2 |
| Pete Sampras | 6 --- AO 1, WM 2, US 3 |
| Mats Wilander | 5 --- AO 2, RG 2, US 1 |
| John McEnroe | 4 --- AO 1, WM 1, US 2 |
| Novak Djokovic | 4 --- AO 2, WM 1, US 1 |
| Marat Safin | 3 --- AO 2, RG 1 |
| Ken Rosewall | 3 --- AO 2, US 1 |
| Boris Becker | 3 --- AO 1, WM 2 |
| Michael Chang | 2 --- AO 1, RG 1 |
| Karol Kucera | 2 --- AO 1, RG 1 |
| Stefan Edberg | 2 --- AO 1, WM 1 |
| Andy Murray | 2 --- AO 1, US 1 |
| Stanislas Wawrinka | 2 --- AO 1, US 1 |
| Andrei Chesnokov | 2 --- RG 2 |
| Robin Soderling | 2 --- RG |
| Michael Stich | 2 --- RG 1, WM 1 |
| Bjorn Borg | 2 --- RG 1, US 1 |
| Rod Laver | 2 --- RG 1, US 1 |
| Guillermo Vilas | 2 --- RG 1, US 1 |
| Kevin Curren | 2 --- WM 2 |
| Jimmy Connors | 2 --- WM 2 |
| Roger Federer | 2 --- WM 2 |
| Arthur Ashe | 2 --- WM 1, US 1 |
| Ivan Lendl | 2 --- US 2 |
| Karl Meiler | 1 --- AO |
| Ross Case | 1 --- AO |
| John Newcombe | 1 --- AO |
| Mark Edmondson | 1 --- AO |
| Chris Lewis | 1 --- AO |
| Kim Warwick | 1 --- AO |
| Ramesh Krishnan | 1 --- AO |
| Carlos Moya | 1 --- AO |
| Todd Martin | 1 --- AO |
| Andy Roddick | 1 --- AO |
| Patrick Proisy | 1 --- RG |
| Harold Solomon | 1 --- RG |
| Adriano Panatta | 1 --- RG |
| Raul Ramirez | 1 --- RG |
| Yannick Noah | 1 --- RG |
| Jonas Svensson | 1 --- RG |
| Sergi Bruguera | 1 --- RG |
| Gustavo Kuerten | 1 --- RG |
| Albert Costa | 1 --- RG |
| Juan Carlos Ferrero | 1 --- RG |
| Igor Andreev | 1 --- RG |
| David Ferrer | 1 --- RG |
| Roger Taylor | 1 --- WM |
| Vitas Gerulaitis | 1 --- WM |
| Peter Doohan | 1 --- WM |
| Richard Krajicek | 1 --- WM |
| Tim Henman | 1 --- WM |
| Ivo Karlovic | 1 --- WM |
| Rafael Nadal | 1 --- WM |
| Tomas Berdych | 1 --- WM |
| Sergiy Stakhovsky | 1 --- WM |
| Dennis Ralston | 1 --- US |
| Andrew Pattison | 1 --- US |
| Manuel Orantes | 1 --- US |
| Butch Walts | 1 --- US |
| Jim Courier | 1 --- US |
| Karel Novacek | 1 --- US |
| Jaime Yzaga | 1 --- US |
| Petr Korda | 1 --- US |
| Cedric Pioline | 1 --- US |
| Arnaud Clement | 1 --- US |
| Joachim Johansson | 1 --- US |
| Juan Martin Del Potro | 1 --- US |
Defeated three Def. Champs, same year
Novak Djokovic 2011
d. Roger Federer, Australian Open SF
d. Rafael Nadal, Wimbledon F
d. Rafael Nadal, US Open F
Defeated two Def. Champs, same year
Rod Laver 1969
d. Ken Rosewal, Roland Garros F
d. Arthur Ashe, US Open SF
Mats Wilander 1988
d. Stefan Edberg, Australian Open SF
d. Ivan Lendl, US Open F
Andre Agassi 1990
d. Michael Chang, Roland Garros QF
d. Boris Becker, US Open SF
Novak Djokovic 2011
d. Roger Federer, Australian Open SF
d. Rafael Nadal, Wimbledon F
d. Rafael Nadal, US Open F
Defeated two Def. Champs, same year
Rod Laver 1969
d. Ken Rosewal, Roland Garros F
d. Arthur Ashe, US Open SF
Mats Wilander 1988
d. Stefan Edberg, Australian Open SF
d. Ivan Lendl, US Open F
Andre Agassi 1990
d. Michael Chang, Roland Garros QF
d. Boris Becker, US Open SF